Siri co-founder talks to iMore about the future of technology, mobile interfaces, and implementing Siri

Dag Kittlaus, creator of Siri, recently spoke at an economic development event in his hometown of Michigan City, Indiana, and iMore had the chance to listen in and ask him some question about the challenges they faced in implementing Siri and where he thinks the future of technology is headed.

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PSA: Sprint's LTE-infused Galaxy Nexus now available online and in stores

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Google itself may have thrown the pricing situation out of whack by offering up a contract-free GSM version of Samsung's Galaxy Nexus for just $399, but those adhering to Sprint's plans can't make use of that, anyway. The other CDMA / LTE-infused Galaxy Nexus is now shipping from Sprint, several months ahead of its first LTE rollout. $199.99 on a two-year contract nets you a device, while you can snag one for $549.99 sans any strings. It's also available in stores nationwide for those who'd prefer to try before they buy, and yes, Sprint users who activate a Google Wallet account within a week of activation will receive a $10 instant credit and an additional $40 within three weeks. Just try to ignore that Galaxy S III that'll launch next month, okay? (It's not a pure Google device, anyway.)

PSA: Sprint's LTE-infused Galaxy Nexus now available online and in stores originally appeared on Engadget on Wed, 25 Apr 2012 17:59:00 EDT. Please see our terms for use of feeds.

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App-Enhanced Pavement Turns Roads Into Wireless Hotspots [Video]

A Spanish company called V?a Inteligente has created a unique smart paving stone with a built-in computer as well as Wi-Fi and Bluetooth. They're designed as an easy way to provide wireless access to various services without the need for a hotspot or an ugly antenna, but it also has the potential to easily create an expansive wireless network in urban areas. More »


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Apple CEO Tim Cook Made a Funny! (Updated) [Apple]

During Apple's call today to discuss its monster earnings last quarter, CEO Tim Cook was asked his opinion on Windows 8. He said all of the expected things about how the iPad has unlimited potential, but also weighed in on tablet-PC hybrid devices with this little bon mot: More »


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Of Course Ikea's Digital Camera Is Made of Cardboard [Cameras]

In the press kits they distributed last week at Milan's Salone design show, Ikea included a very Ikea product: a digital camera made of cardboard. The camera, which runs on two AA batteries and can hold up to 40 images on a built-in memory stick, can be synced with a computer via the USB that swings out from its side. It will soon be available for sale in Ikea stores—though, given Ikea's reputation for less than stellar merch, it might be wise to consider your options. More »


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Finance Zone ? Blog Archive ? instant payday loans online

Hello readers! I am back with an interesting and informative finance related article which is about online pay day loans no credit check. In this article you can find out some useful information about UK payday loans. This article will help you to find the best pay day loan website to get instant payday loans online. The online payday loans are provided by most of the financial institutions in order to cover the customers instant needs like paying electricity bills, telephone bills, house rent and many other expenses.

If you apply for the payday loans then you can get it within 24 hours. You can apply for UK loans for bad credit ?from your home through online with the help of internet service. There are many online payday loan websites available at UK. You need to find the best online payday loan website that offer top quality service. The best UK online payday loan website that I recommend you to approach is britainloans.co.uk, they are one of the leading providers of online payday loans for the UK customers.

April 23rd, 2012 in Uncategorized

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Just Show Me: How to delete pictures from Photo Stream

Welcome to?Just Show Me on?Tecca TV, where we show you some tips and tricks for getting the most out of the?gadgets in your life. In today's episode we'll show you how to take pictures out of your?Photo Stream. If you don't want to let an unwanted picture clutter up your Photo Stream, there's no reason to leave it in place. Getting it out is easy!

For even more episodes of Just Show Me,?check out all our Just Show Me episodes. If you have any topics you'd like to see us cover, just drop us a line in the comments.

This article originally appeared on Tecca

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Unusual protein helps regulate key cell communication pathway

ScienceDaily (Apr. 23, 2012) ? Tiny pores, or channels, embedded in cell membranes are critical to the healthy functioning of cells. Charged atoms, or ions, move through these channels to generate the electrical signals that allow cells to communicate with one another.

New research at Washington University School of Medicine in St. Louis unveils some of the inner workings of certain channels involved in regulating electrical signals in nerve cells, relaxing muscle cells and "tuning" hair cells in the inner ear.

In a report published April 22 in the advance online edition of the journal Nature, the scientists have shown how an unusual protein -- one lacking any definable structure -- plays a key role in temporarily blocking the movement of ions through these channels after a cell fires off an electrical signal. Preventing ions from moving through the channel is important because it gives cells time to recharge so that they can continue firing.

The researchers studied large potassium channels, called BK channels, which allow potassium ions to move in and out of cells. Looking at the channels gave the Washington University researchers an opportunity to see how so-called intrinsically disordered proteins can operate in cells.

They found that an intrinsically disordered protein was responsible for inactivating the BK channel. These proteins are of particular interest to scientists because they defy the long-held notion that a protein's precise 3-dimensional form determines its function.

Lingle, a professor of anesthesiology and of neurobiology, and his colleagues monitored the electrical activity of BK channels as they opened and closed. Despite the disordered nature of the unstructured protein that closes the channel, the researchers found that it nestles into a receptor inside the BK channel in a highly specific way. This lock-and-key mechanism is essential to closing, or inactivating, the channel.

"It's a two-step process, which distinguishes it from most other inactivation mechanisms that have been described," Lingle says. "My guess is that the part of the protein that binds to the potassium channel receptor may have to move through some very narrow spaces. It may be that by having a less-defined structure, the protein can navigate more easily through tight spaces and to get to the binding site."

Lingle and his colleagues are currently attempting to study how the channels behave in mouse cells to learn more about the physiological effects of BK channel behavior.

Problems in regulating BK channels are known to be involved in epilepsy, asthma and cardiovascular disease. A better understanding of the way those channels operate might help scientists think about new ways to treat these conditions and determine why the disordered protein domains that regulate these channels don't have a well-defined structure.

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The above story is reprinted from materials provided by Washington University School of Medicine. The original article was written by Jim Dryden.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Vivian Gonzalez-Perez, Xu-Hui Zeng, Katie Henzler-Wildman, Christopher J. Lingle. Stereospecific binding of a disordered peptide segment mediates BK channel inactivation. Nature, 2012; DOI: 10.1038/nature10994

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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iPhone and iPad theft in New York up 44% since last year

Recent data from the New York Police Department shows that the theft of iPhone and iPads have increased by 44% since last year. From the beginning of the year to April 15, 1,196 iOS devices have been stolen, while 831 were swiped during the same period in 2011.

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